Assay Detail
Binding
CHEMBL649053
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Displacement of specific [125I]AB-MECA binding at human adenosine A3 receptor expressed in CHO cells
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of a new set of 2-arylpyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 7.21 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322983 | — | — | 1 | 8.68 |
| CHEMBL106740 | — | — | 1 | 8.54 |
| CHEMBL242202 | — | — | 1 | 8.49 |
| CHEMBL242203 | — | — | 1 | 8.49 |
| CHEMBL387592 | — | — | 1 | 8.30 |
| CHEMBL107571 | — | — | 1 | 8.08 |
| CHEMBL320283 | — | — | 1 | 8.00 |
| CHEMBL107414 | — | — | 1 | 7.65 |
| CHEMBL241987 | — | — | 1 | 7.51 |
| CHEMBL106986 | — | — | 1 | 7.48 |
| CHEMBL107116 | — | — | 1 | 7.45 |
| CHEMBL104478 | — | — | 1 | 7.36 |
| CHEMBL442005 | — | — | 1 | 7.36 |
| CHEMBL322228 | — | — | 1 | 7.34 |
| CHEMBL320741 | — | — | 1 | 7.32 |
| CHEMBL318323 | — | — | 1 | 7.25 |
| CHEMBL106520 | — | — | 1 | 7.22 |
| CHEMBL320093 | — | — | 1 | 7.17 |
| CHEMBL324419 | — | — | 1 | 7.10 |
| CHEMBL105913 | — | — | 1 | 7.04 |
| CHEMBL107446 | — | — | 1 | 7.00 |
| CHEMBL108178 | — | — | 1 | 6.97 |
| CHEMBL106906 | — | — | 1 | 6.94 |
| CHEMBL106040 | — | — | 1 | 6.93 |
| CHEMBL419002 | — | — | 1 | 6.82 |
| CHEMBL104178 | — | — | 1 | 6.82 |
| CHEMBL104177 | — | — | 1 | 6.81 |
| CHEMBL106346 | — | — | 1 | 6.73 |
| CHEMBL322263 | — | — | 1 | 6.51 |
| CHEMBL320805 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322983 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL106740 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL242202 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL242203 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL387592 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL107571 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL320283 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL107414 | — | Ki | = | 22.3 | nM | 7.65 |
| CHEMBL241987 | — | Ki | = | 30.8 | nM | 7.51 |
| CHEMBL106986 | — | Ki | = | 32.9 | nM | 7.48 |
| CHEMBL107116 | — | Ki | = | 35.8 | nM | 7.45 |
| CHEMBL104478 | — | Ki | = | 44.1 | nM | 7.36 |
| CHEMBL442005 | — | Ki | = | 44.1 | nM | 7.36 |
| CHEMBL322228 | — | Ki | = | 45.3 | nM | 7.34 |
| CHEMBL320741 | — | Ki | = | 48.2 | nM | 7.32 |
| CHEMBL318323 | — | Ki | = | 56.5 | nM | 7.25 |
| CHEMBL106520 | — | Ki | = | 60.5 | nM | 7.22 |
| CHEMBL320093 | — | Ki | = | 68.4 | nM | 7.17 |
| CHEMBL324419 | — | Ki | = | 79.2 | nM | 7.10 |
| CHEMBL105913 | — | Ki | = | 90.2 | nM | 7.04 |
| CHEMBL107446 | — | Ki | = | 99.3 | nM | 7.00 |
| CHEMBL108178 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL106906 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL106040 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL419002 | — | Ki | = | 152.0 | nM | 6.82 |
| CHEMBL104178 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL104177 | — | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL106346 | — | Ki | = | 188.0 | nM | 6.73 |
| CHEMBL322263 | — | Ki | = | 309.0 | nM | 6.51 |
| CHEMBL320805 | — | Ki | = | 551.0 | nM | 6.26 |
| CHEMBL104115 | — | Ki | = | 707.0 | nM | 6.15 |
| CHEMBL321441 | — | Ki | = | 788.0 | nM | 6.10 |
| CHEMBL104425 | — | Ki | = | 2128.0 | nM | 5.67 |
| CHEMBL107637 | — | Ki | = | 3600.0 | nM | 5.44 |