Assay Detail
Binding
CHEMBL1798413
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Inhibition of bovine Xanthine oxidase assessed as reduction in uric acid level by spectrophotometry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel xanthone derivatives as xanthine oxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.06 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1795514 | — | — | 1 | 5.33 |
| CHEMBL1795523 | — | — | 1 | 5.33 |
| CHEMBL1795508 | — | — | 1 | 5.24 |
| CHEMBL1795512 | — | — | 1 | 5.19 |
| CHEMBL1795506 | — | — | 1 | 5.15 |
| CHEMBL1795507 | — | — | 1 | 4.87 |
| CHEMBL1795517 | — | — | 1 | 4.70 |
| CHEMBL187265 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1795514 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1795523 | — | IC50 | = | 4670.0 | nM | 5.33 |
| CHEMBL1795508 | — | IC50 | = | 5730.0 | nM | 5.24 |
| CHEMBL1795512 | — | IC50 | = | 6410.0 | nM | 5.19 |
| CHEMBL1795506 | — | IC50 | = | 7080.0 | nM | 5.15 |
| CHEMBL1795507 | — | IC50 | = | 13560.0 | nM | 4.87 |
| CHEMBL1795517 | — | IC50 | = | 20060.0 | nM | 4.70 |
| CHEMBL187265 | — | IC50 | = | 21730.0 | nM | 4.66 |