Assay Detail
Binding
CHEMBL1798415
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p38alpha kinase
11
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Substituted N-aryl-6-pyrimidinones: a new class of potent, selective, and orally active p38 MAP kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.56 | 8.22 |
| Ki | 2 | 7.63 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1088751 | PH-797804 | 2.0 | 1 | 8.54 |
| CHEMBL1795684 | — | — | 1 | 8.22 |
| CHEMBL1795686 | — | — | 1 | 7.96 |
| CHEMBL1795683 | — | — | 1 | 7.92 |
| CHEMBL1795682 | — | — | 1 | 7.57 |
| CHEMBL1738710 | — | — | 2 | 7.54 |
| CHEMBL1795681 | — | — | 1 | 7.52 |
| CHEMBL1795685 | — | — | 1 | 7.42 |
| CHEMBL1795687 | — | — | 1 | 7.22 |
| CHEMBL1795688 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1088751 | PH-797804 | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL1795684 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1795686 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1795683 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1795682 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1738710 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1795681 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1795685 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1795687 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1738710 | — | Ki | = | 193.0 | nM | 6.71 |
| CHEMBL1795688 | — | IC50 | = | 193.0 | nM | 6.71 |