Assay Detail
Binding
CHEMBL1798501
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Inhibition of Sirt2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Computer- and structure-based lead design for epigenetic targets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.61 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL224864 | — | — | 1 | 5.46 |
| CHEMBL425294 | — | — | 1 | 4.24 |
| CHEMBL220458 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL224864 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL425294 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL220458 | — | IC50 | = | 74000.0 | nM | 4.13 |