Assay Detail
Binding
CHEMBL1798563
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Inhibition of LSD1
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 1A (CHEMBL6136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitors of histone demethylases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.95 | 7.30 |
| IC50 | 5 | 5.31 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1797647 | — | — | 1 | 7.30 |
| CHEMBL1795980 | — | — | 1 | 6.21 |
| CHEMBL1797651 | — | — | 1 | 6.16 |
| CHEMBL1797650 | — | — | 1 | 6.05 |
| CHEMBL1795981 | — | — | 1 | 6.00 |
| CHEMBL1797640 | — | — | 1 | 6.00 |
| CHEMBL1797641 | — | — | 1 | 6.00 |
| CHEMBL1797645 | — | — | 1 | 5.82 |
| CHEMBL1797646 | — | — | 1 | 5.75 |
| CHEMBL1215658 | — | — | 1 | 5.70 |
| CHEMBL1797639 | — | — | 1 | 5.70 |
| CHEMBL1797652 | — | — | 1 | 5.36 |
| CHEMBL1797642 | — | — | 1 | 5.05 |
| CHEMBL1797643 | — | — | 1 | 5.05 |
| CHEMBL1797644 | — | — | 1 | 5.05 |
| CHEMBL1089 | PHENELZINE | 4.0 | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1797647 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL1795980 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL1797651 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL1797650 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL1795981 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1797640 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1797641 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1797645 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL1797646 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL1215658 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1797639 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1797652 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL1797642 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1797643 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1797644 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1089 | PHENELZINE | Ki | = | 17600.0 | nM | 4.75 |