Assay Detail
Binding
CHEMBL1798602
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p38alpha kinase in human monocytes
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Substituted N-aryl-6-pyrimidinones: a new class of potent, selective, and orally active p38 MAP kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.77 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1738710 | — | — | 1 | 7.77 |
| CHEMBL1088751 | PH-797804 | 2.0 | 1 | 7.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1738710 | — | IC50 | = | 16.9 | nM | 7.77 |
| CHEMBL1088751 | PH-797804 | IC50 | = | 17.4 | nM | 7.76 |