Assay Detail
Binding
CHEMBL1799090
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Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid lipoxygenase ALOX15 (CHEMBL4358) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.56 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1796849 | — | — | 1 | 8.62 |
| CHEMBL1796851 | — | — | 1 | 8.51 |
| CHEMBL1796850 | — | — | 1 | 8.39 |
| CHEMBL1796845 | — | — | 1 | 8.37 |
| CHEMBL1796847 | — | — | 1 | 8.15 |
| CHEMBL1796846 | — | — | 1 | 8.15 |
| CHEMBL1796844 | — | — | 1 | 8.12 |
| CHEMBL1796848 | — | — | 1 | 8.09 |
| CHEMBL1795361 | — | — | 1 | 7.82 |
| CHEMBL1796840 | — | — | 1 | 7.72 |
| CHEMBL1796839 | — | — | 1 | 7.55 |
| CHEMBL1796842 | — | — | 1 | 7.44 |
| CHEMBL1796841 | — | — | 1 | 7.28 |
| CHEMBL1796843 | — | — | 1 | 7.19 |
| CHEMBL1796837 | — | — | 1 | 6.50 |
| CHEMBL1796836 | — | — | 1 | 6.28 |
| CHEMBL1796838 | — | — | 1 | 6.04 |
| CHEMBL1796834 | — | — | 1 | 5.81 |
| CHEMBL1796832 | — | — | 1 | - |
| CHEMBL1796835 | — | — | 1 | - |
| CHEMBL1796833 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1796849 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL1796851 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL1796850 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL1796845 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1796847 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1796846 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1796844 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL1796848 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL1795361 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1796840 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1796839 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1796842 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1796841 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL1796843 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1796837 | — | IC50 | = | 313.0 | nM | 6.50 |
| CHEMBL1796836 | — | IC50 | = | 524.0 | nM | 6.28 |
| CHEMBL1796838 | — | IC50 | = | 918.0 | nM | 6.04 |
| CHEMBL1796834 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL1796832 | — | IC50 | - | — | - | |
| CHEMBL1796835 | — | IC50 | - | — | - | |
| CHEMBL1796833 | — | IC50 | - | — | - |