Assay Detail
Binding
CHEMBL1799091
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid lipoxygenase ALOX15 (CHEMBL4358) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.80 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1796851 | — | — | 1 | 8.85 |
| CHEMBL1796845 | — | — | 1 | 8.82 |
| CHEMBL1796849 | — | — | 1 | 8.74 |
| CHEMBL1796846 | — | — | 1 | 8.70 |
| CHEMBL1796850 | — | — | 1 | 8.57 |
| CHEMBL1796847 | — | — | 1 | 8.52 |
| CHEMBL1796844 | — | — | 1 | 8.44 |
| CHEMBL1796840 | — | — | 1 | 8.40 |
| CHEMBL1795361 | — | — | 1 | 8.38 |
| CHEMBL1796848 | — | — | 1 | 8.28 |
| CHEMBL1796841 | — | — | 1 | 8.05 |
| CHEMBL1796842 | — | — | 1 | 8.00 |
| CHEMBL1796839 | — | — | 1 | 7.96 |
| CHEMBL1796843 | — | — | 1 | 7.92 |
| CHEMBL1796837 | — | — | 1 | 7.46 |
| CHEMBL1796836 | — | — | 1 | 7.17 |
| CHEMBL1796834 | — | — | 1 | 6.82 |
| CHEMBL1796838 | — | — | 1 | 6.80 |
| CHEMBL1796833 | — | — | 1 | 6.52 |
| CHEMBL1796835 | — | — | 1 | 5.91 |
| CHEMBL1796832 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1796851 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1796845 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL1796849 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1796846 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1796850 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL1796847 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1796844 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL1796840 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1795361 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL1796848 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL1796841 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1796842 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1796839 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1796843 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1796837 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1796836 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1796834 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1796838 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL1796833 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL1796835 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL1796832 | — | IC50 | = | 3980.0 | nM | 5.40 |