Assay Detail
Binding
CHEMBL1799221
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Inhibition of Enterobacter cloacae beta lactamase P99
12
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Enterobacter cloacae |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thiophenyl oxime-derived phosphonates as nano-molar class C beta-lactamase inhibitors reducing MIC of imipenem against Pseudomonas aeruginosa and Acinetobacter baumannii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.62 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1795572 | — | — | 1 | 7.72 |
| CHEMBL1795567 | — | — | 1 | 7.50 |
| CHEMBL1795565 | — | — | 1 | 7.41 |
| CHEMBL1795571 | — | — | 2 | 7.06 |
| CHEMBL1795566 | — | — | 1 | 7.00 |
| CHEMBL1795568 | — | — | 1 | 7.00 |
| CHEMBL1795564 | — | — | 2 | 6.47 |
| CHEMBL1795563 | — | — | 1 | 6.10 |
| CHEMBL1795570 | — | — | 1 | 5.52 |
| CHEMBL1795569 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1795572 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1795567 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1795565 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1795571 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL1795566 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1795568 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1795571 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1795564 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1795564 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL1795563 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1795570 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1795569 | — | IC50 | = | 21000.0 | nM | 4.68 |