Assay Detail
Functional
CHEMBL1799233
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Antiproliferative activity against human HCT116 cells after 72 hrs by cell counting kit analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.23 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1795731 | — | — | 1 | 6.22 |
| CHEMBL1795737 | — | — | 1 | 6.22 |
| CHEMBL1795732 | — | — | 1 | 6.16 |
| CHEMBL1795736 | — | — | 1 | 5.92 |
| CHEMBL1795734 | — | — | 1 | 5.21 |
| CHEMBL1795741 | — | — | 1 | 4.75 |
| CHEMBL1795738 | — | — | 1 | 4.71 |
| CHEMBL1795740 | — | — | 1 | 4.61 |
| CHEMBL1795733 | — | — | 1 | 4.32 |
| CHEMBL228226 | — | — | 1 | 4.17 |
| CHEMBL1795735 | — | — | 1 | - |
| CHEMBL115523 | N-PHENYLBENZAMIDE | — | 1 | - |
| CHEMBL1795739 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1795731 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1795737 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1795732 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1795736 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1795734 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1795741 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL1795738 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL1795740 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL1795733 | — | IC50 | = | 47600.0 | nM | 4.32 |
| CHEMBL228226 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL1795735 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL115523 | N-PHENYLBENZAMIDE | IC50 | > | 100000.0 | nM | - |
| CHEMBL1795739 | — | IC50 | > | 100000.0 | nM | - |