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Assay Detail

CHEMBL1799389

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Binding
Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader based method
ChEMBL ↗
322
Total Activities
161
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Glycogen phosphorylase, muscle form (CHEMBL4696) ↗
Type SINGLE PROTEIN
Organism Oryctolagus cuniculus

Publication

Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.
Liang Z, Zhang L, Li L, Liu J, Li H, Zhang L, Chen L, Cheng K, Zheng M, Wen X, Zhang P, Hao J, Gong Y, Zhang X, Zhu X, Chen J, Liu H, Jiang H, Luo C, Sun H.
Eur J Med Chem (2011) 46 : 2011 -2021
PubMed 21439694 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 322 4.70 5.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL574993 — — 2 5.96
CHEMBL1796866 — — 2 5.94
CHEMBL1797018 — — 2 5.90
CHEMBL1797010 — — 2 5.82
CHEMBL1796873 — — 2 5.67
CHEMBL1796878 — — 2 5.65
CHEMBL1797012 — — 2 5.59
CHEMBL1797021 — — 2 5.51
CHEMBL1078407 — — 2 5.50
CHEMBL238219 — — 2 5.49
CHEMBL1796879 — — 2 5.49
CHEMBL1797139 — — 2 5.48
CHEMBL1797138 — — 2 5.39
CHEMBL1077661 — — 2 5.38
CHEMBL395906 — — 2 5.29
CHEMBL1796874 — — 2 5.27
CHEMBL1797023 — — 2 5.27
CHEMBL577380 BREDEMOLIC ACID — 2 5.20
CHEMBL1797014 — — 2 5.18
CHEMBL1797022 — — 2 5.18
CHEMBL372331 — — 2 5.16
CHEMBL392670 — — 2 5.14
CHEMBL574391 — — 2 5.11
CHEMBL1796876 — — 2 5.11
CHEMBL1797317 — — 2 5.10
CHEMBL1797426 — — 2 5.09
CHEMBL169 URSOLIC ACID 2.0 2 5.05
CHEMBL1797306 — — 2 5.00
CHEMBL1796880 — — 2 4.99
CHEMBL1797016 — — 2 4.98

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL574993 — IC50 = 1100.0 nM 5.96
CHEMBL574993 — IC50 = 1096.48 nM 5.96
CHEMBL1796866 — IC50 = 1140.0 nM 5.94
CHEMBL1796866 — IC50 = 1148.15 nM 5.94
CHEMBL1797018 — IC50 = 1258.93 nM 5.90
CHEMBL1797018 — IC50 = 1250.0 nM 5.90
CHEMBL1797010 — IC50 = 1513.56 nM 5.82
CHEMBL1797010 — IC50 = 1530.0 nM 5.82
CHEMBL1796873 — IC50 = 2137.96 nM 5.67
CHEMBL1796873 — IC50 = 2130.0 nM 5.67
CHEMBL1796878 — IC50 = 2238.72 nM 5.65
CHEMBL1796878 — IC50 = 2230.0 nM 5.65
CHEMBL1797012 — IC50 = 2590.0 nM 5.59
CHEMBL1797012 — IC50 = 2570.4 nM 5.59
CHEMBL1797021 — IC50 = 3090.3 nM 5.51
CHEMBL1797021 — IC50 = 3070.0 nM 5.51
CHEMBL1078407 — IC50 = 3200.0 nM 5.50
CHEMBL1796879 — IC50 = 3235.94 nM 5.49
CHEMBL238219 — IC50 = 3260.0 nM 5.49
CHEMBL1078407 — IC50 = 3235.94 nM 5.49
CHEMBL238219 — IC50 = 3235.94 nM 5.49
CHEMBL1796879 — IC50 = 3250.0 nM 5.49
CHEMBL1797139 — IC50 = 3300.0 nM 5.48
CHEMBL1797139 — IC50 = 3311.31 nM 5.48
CHEMBL1797138 — IC50 = 4100.0 nM 5.39
CHEMBL1797138 — IC50 = 4073.8 nM 5.39
CHEMBL1077661 — IC50 = 4200.0 nM 5.38
CHEMBL1077661 — IC50 = 4168.69 nM 5.38
CHEMBL395906 — IC50 = 5100.0 nM 5.29
CHEMBL395906 — IC50 = 5128.61 nM 5.29
CHEMBL1796874 — IC50 = 5370.32 nM 5.27
CHEMBL1797023 — IC50 = 5370.32 nM 5.27
CHEMBL1796874 — IC50 = 5390.0 nM 5.27
CHEMBL1797023 — IC50 = 5350.0 nM 5.27
CHEMBL577380 BREDEMOLIC ACID IC50 = 6309.57 nM 5.20
CHEMBL577380 BREDEMOLIC ACID IC50 = 6250.0 nM 5.20
CHEMBL1797022 — IC50 = 6606.93 nM 5.18
CHEMBL1797022 — IC50 = 6540.0 nM 5.18
CHEMBL1797014 — IC50 = 6590.0 nM 5.18
CHEMBL1797014 — IC50 = 6606.93 nM 5.18
CHEMBL372331 — IC50 = 7000.0 nM 5.16
CHEMBL372331 — IC50 = 7079.46 nM 5.15
CHEMBL392670 — IC50 = 7244.36 nM 5.14
CHEMBL392670 — IC50 = 7310.0 nM 5.14
CHEMBL574391 — IC50 = 7800.0 nM 5.11
CHEMBL1796876 — IC50 = 7762.47 nM 5.11
CHEMBL574391 — IC50 = 7762.47 nM 5.11
CHEMBL1796876 — IC50 = 7760.0 nM 5.11
CHEMBL1797317 — IC50 = 8000.0 nM 5.10
CHEMBL1797317 — IC50 = 7943.28 nM 5.10