Assay Detail
Functional
CHEMBL1799418
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Antitrypanosomal activity against Trypanosoma brucei brucei
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
SAR of 2-amino and 2,4-diamino pyrimidines with in vivo efficacy against Trypanosoma brucei.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 6.32 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1795651 | — | — | 1 | 7.52 |
| CHEMBL1795634 | — | — | 1 | 7.37 |
| CHEMBL1795628 | — | — | 1 | 7.35 |
| CHEMBL1795635 | — | — | 1 | 7.19 |
| CHEMBL1795629 | — | — | 1 | 7.06 |
| CHEMBL1795638 | — | — | 1 | 6.96 |
| CHEMBL1795637 | — | — | 1 | 6.96 |
| CHEMBL1795633 | — | — | 1 | 6.89 |
| CHEMBL268507 | — | — | 1 | 6.77 |
| CHEMBL1795652 | — | — | 1 | 6.77 |
| CHEMBL1795639 | — | — | 1 | 6.72 |
| CHEMBL1795653 | — | — | 1 | 6.58 |
| CHEMBL1795631 | — | — | 1 | 6.54 |
| CHEMBL1795640 | — | — | 1 | 6.54 |
| CHEMBL1795656 | — | — | 1 | 6.51 |
| CHEMBL1795654 | — | — | 1 | 6.48 |
| CHEMBL1795626 | — | — | 1 | 6.47 |
| CHEMBL1795641 | — | — | 1 | 6.44 |
| CHEMBL1795627 | — | — | 1 | 6.43 |
| CHEMBL1795636 | — | — | 1 | 6.39 |
| CHEMBL1795349 | — | — | 1 | 6.24 |
| CHEMBL216126 | — | — | 1 | 6.18 |
| CHEMBL1795630 | — | — | 1 | 5.82 |
| CHEMBL1795655 | — | — | 1 | 5.80 |
| CHEMBL1795657 | — | — | 1 | 5.75 |
| CHEMBL1795648 | — | — | 1 | 5.75 |
| CHEMBL1795632 | — | — | 1 | 5.51 |
| CHEMBL217537 | — | — | 1 | 5.48 |
| CHEMBL1795644 | — | — | 1 | 5.35 |
| CHEMBL1795643 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1795651 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1795634 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1795628 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1795635 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1795629 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL1795638 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1795637 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1795633 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL268507 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1795652 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1795639 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1795653 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1795631 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1795640 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1795656 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1795654 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1795626 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1795641 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL1795627 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1795636 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1795349 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL216126 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL1795630 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL1795655 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1795657 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1795648 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1795632 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL217537 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1795644 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1795643 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1795646 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1795647 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL1795649 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1795650 | — | IC50 | > | 12000.0 | nM | - |
| CHEMBL1795645 | — | IC50 | > | 12000.0 | nM | - |
| CHEMBL1795642 | — | IC50 | > | 11000.0 | nM | - |
| CHEMBL1795658 | — | IC50 | > | 12000.0 | nM | - |
| CHEMBL387448 | — | IC50 | > | 14000.0 | nM | - |