Assay Detail
Binding
CHEMBL1799477
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine lens ALR2
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Lens of camera-type eye |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL3081) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.13 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1645381 | — | — | 1 | 7.16 |
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 6.77 |
| CHEMBL1796882 | — | — | 1 | 6.60 |
| CHEMBL1796755 | — | — | 1 | 6.57 |
| CHEMBL1796887 | — | — | 1 | 6.52 |
| CHEMBL1796881 | — | — | 1 | 6.46 |
| CHEMBL1796886 | — | — | 1 | 6.07 |
| CHEMBL1796885 | — | — | 1 | 5.98 |
| CHEMBL1796883 | — | — | 1 | 5.90 |
| CHEMBL1796884 | — | — | 1 | 5.88 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 5.70 |
| CHEMBL1796890 | — | — | 1 | 5.57 |
| CHEMBL1796888 | — | — | 1 | 5.36 |
| CHEMBL1796889 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1645381 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL56337 | EPALRESTAT | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1796882 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1796755 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1796887 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1796881 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1796886 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL1796885 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL1796883 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL1796884 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL266497 | SORBINIL | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1796890 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1796888 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1796889 | — | IC50 | = | 4900.0 | nM | 5.31 |