Assay Detail
Binding
CHEMBL1799647
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Inhibition of human MMP1 by fluorometric assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.20 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514138 | CGS-27023A | — | 1 | 7.25 |
| CHEMBL1795859 | — | — | 1 | 5.64 |
| CHEMBL1795857 | — | — | 1 | 5.32 |
| CHEMBL1795862 | — | — | 1 | 5.17 |
| CHEMBL1795351 | — | — | 1 | 4.89 |
| CHEMBL1795861 | — | — | 1 | 4.68 |
| CHEMBL1795858 | — | — | 1 | 4.43 |
| CHEMBL1795860 | — | — | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514138 | CGS-27023A | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL1795859 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1795857 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL1795862 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL1795351 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1795861 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL1795858 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL1795860 | — | IC50 | = | 56000.0 | nM | 4.25 |