Assay Detail
Binding
CHEMBL1799651
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Inhibition of human MMP9 by fluorometric assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.41 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1795862 | — | — | 1 | 8.37 |
| CHEMBL514138 | CGS-27023A | — | 1 | 8.32 |
| CHEMBL1795861 | — | — | 1 | 7.68 |
| CHEMBL1795858 | — | — | 1 | 7.30 |
| CHEMBL1795857 | — | — | 1 | 7.20 |
| CHEMBL1795859 | — | — | 1 | 7.11 |
| CHEMBL1795351 | — | — | 1 | 7.10 |
| CHEMBL1795860 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1795862 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL1795861 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1795858 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1795857 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL1795859 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL1795351 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL1795860 | — | IC50 | = | 650.0 | nM | 6.19 |