Assay Detail
Functional
CHEMBL1803176
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Antiviral activity against Cowpox virus Brighton infected in HFF cells assessed as reduction in plaque formation after 3 days
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cowpox virus (Brighton Red) |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, transport and antiviral activity of Ala-Ser and Val-Ser prodrugs of cidofovir.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.52 | 4.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 4.52 |
| CHEMBL392630 | CYCLIC CIDOFOVIR | — | 1 | 4.52 |
| CHEMBL1802859 | — | — | 1 | - |
| CHEMBL1802860 | — | — | 1 | - |
| CHEMBL1802862 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL392630 | CYCLIC CIDOFOVIR | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1802859 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1802860 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1802862 | — | IC50 | > | 30000.0 | nM | - |