Assay Detail
ADMET
CHEMBL1803231
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Cytotoxicity at rat L6 cells after 72 hrs by microplate alamar blue assay
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial pyrido[1,2-a]benzimidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 4.82 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 8.05 |
| CHEMBL1800630 | — | — | 1 | 5.65 |
| CHEMBL1800559 | — | — | 1 | 5.61 |
| CHEMBL1802552 | — | — | 1 | 5.36 |
| CHEMBL1802863 | — | — | 1 | 5.29 |
| CHEMBL1802542 | — | — | 1 | 5.23 |
| CHEMBL1802551 | — | — | 1 | 5.20 |
| CHEMBL1802868 | — | — | 1 | 5.15 |
| CHEMBL1800549 | — | — | 1 | 4.94 |
| CHEMBL3216100 | — | — | 1 | 4.93 |
| CHEMBL1802864 | — | — | 1 | 4.93 |
| CHEMBL1802553 | — | — | 1 | 4.92 |
| CHEMBL1800550 | — | — | 1 | 4.81 |
| CHEMBL1802865 | — | — | 1 | 4.72 |
| CHEMBL1802541 | — | — | 1 | 4.71 |
| CHEMBL1802543 | — | — | 1 | 4.71 |
| CHEMBL1800558 | — | — | 1 | 4.67 |
| CHEMBL1800553 | — | — | 1 | 4.61 |
| CHEMBL1802544 | — | — | 1 | 4.54 |
| CHEMBL1800562 | — | — | 1 | 4.48 |
| CHEMBL1802866 | — | — | 1 | 4.40 |
| CHEMBL1802550 | — | — | 1 | 4.39 |
| CHEMBL1802540 | — | — | 1 | 4.35 |
| CHEMBL1800557 | — | — | 1 | 4.31 |
| CHEMBL1802548 | — | — | 1 | 4.25 |
| CHEMBL1800556 | — | — | 1 | 4.25 |
| CHEMBL1479119 | — | — | 1 | 4.06 |
| CHEMBL1800555 | — | — | 1 | 4.06 |
| CHEMBL3216541 | — | — | 1 | 4.05 |
| CHEMBL1800563 | — | — | 1 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1800630 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL1800559 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL1802552 | — | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL1802863 | — | IC50 | = | 5110.0 | nM | 5.29 |
| CHEMBL1802542 | — | IC50 | = | 5880.0 | nM | 5.23 |
| CHEMBL1802551 | — | IC50 | = | 6260.0 | nM | 5.20 |
| CHEMBL1802868 | — | IC50 | = | 7140.0 | nM | 5.15 |
| CHEMBL1800549 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL3216100 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL1802864 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL1802553 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL1800550 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL1802865 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL1802543 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL1802541 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL1800558 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL1800553 | — | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL1802544 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL1800562 | — | IC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL1802866 | — | IC50 | = | 40100.0 | nM | 4.40 |
| CHEMBL1802550 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL1802540 | — | IC50 | = | 44700.0 | nM | 4.35 |
| CHEMBL1800557 | — | IC50 | = | 48800.0 | nM | 4.31 |
| CHEMBL1800556 | — | IC50 | = | 55700.0 | nM | 4.25 |
| CHEMBL1802548 | — | IC50 | = | 56500.0 | nM | 4.25 |
| CHEMBL1479119 | — | IC50 | = | 87800.0 | nM | 4.06 |
| CHEMBL1800555 | — | IC50 | = | 86600.0 | nM | 4.06 |
| CHEMBL3216541 | — | IC50 | = | 89600.0 | nM | 4.05 |
| CHEMBL1800563 | — | IC50 | = | 98300.0 | nM | 4.01 |
| CHEMBL1802545 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL1800551 | — | IC50 | > | 210000.0 | nM | - |
| CHEMBL1800552 | — | IC50 | > | 190000.0 | nM | - |
| CHEMBL1800548 | — | IC50 | = | 166000.0 | nM | - |
| CHEMBL1800554 | — | IC50 | > | 230000.0 | nM | - |
| CHEMBL1802556 | — | IC50 | = | 108000.0 | nM | - |
| CHEMBL1802555 | — | IC50 | = | 180000.0 | nM | - |
| CHEMBL1802554 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1802546 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL1802867 | — | IC50 | > | 210000.0 | nM | - |
| CHEMBL1800561 | — | IC50 | = | 146000.0 | nM | - |
| CHEMBL1802539 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL1800624 | — | IC50 | = | 147200.0 | nM | - |
| CHEMBL1800625 | — | IC50 | > | 175000.0 | nM | - |
| CHEMBL1800627 | — | IC50 | = | 123600.0 | nM | - |
| CHEMBL3217195 | — | IC50 | = | 180000.0 | nM | - |
| CHEMBL3217196 | — | IC50 | > | 190000.0 | nM | - |
| CHEMBL1802549 | — | IC50 | = | 124000.0 | nM | - |
| CHEMBL1802547 | — | IC50 | = | 121000.0 | nM | - |
| CHEMBL1800560 | — | IC50 | = | 193000.0 | nM | - |