Assay Detail
Functional
CHEMBL1803779
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Antiproliferative activity against human CEM cells assessed as growth inhibition after 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Convergent synthesis and biological evaluation of 2-amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as microtubule targeting agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.60 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1800842 | — | — | 1 | 9.05 |
| CHEMBL1800843 | — | — | 1 | 8.85 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.39 |
| CHEMBL1800723 | — | — | 1 | 8.11 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1800842 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1800843 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL1800723 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL53463 | DOXORUBICIN | IC50 | - | — | - | |
| CHEMBL428647 | PACLITAXEL | IC50 | - | — | - |