Assay Detail
Binding
CHEMBL1803809
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Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation counting
23
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.40 | 7.43 |
| Ki | 1 | 8.73 | 8.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1800346 | — | — | 1 | 8.73 |
| CHEMBL447183 | — | — | 1 | 7.43 |
| CHEMBL1800534 | — | — | 1 | 7.41 |
| CHEMBL1800533 | — | — | 1 | 7.26 |
| CHEMBL1800347 | — | — | 1 | 7.15 |
| CHEMBL1738840 | — | — | 1 | 7.09 |
| CHEMBL59925 | — | — | 1 | 6.96 |
| CHEMBL1800348 | — | — | 1 | 6.94 |
| CHEMBL1800528 | — | — | 1 | 6.84 |
| CHEMBL1800523 | — | — | 1 | 6.81 |
| CHEMBL1800526 | — | — | 1 | 6.73 |
| CHEMBL1800527 | — | — | 1 | 6.42 |
| CHEMBL1800531 | — | — | 1 | 6.29 |
| CHEMBL1800532 | — | — | 1 | 6.14 |
| CHEMBL1800530 | — | — | 1 | 6.11 |
| CHEMBL114551 | GW-274150 | 2.0 | 1 | 5.85 |
| CHEMBL1800529 | — | — | 1 | 5.64 |
| CHEMBL7889 | L-NIL | — | 1 | 5.33 |
| CHEMBL51478 | — | — | 1 | 4.97 |
| CHEMBL1800349 | — | — | 1 | 4.31 |
| CHEMBL1800524 | — | — | 1 | - |
| CHEMBL1800525 | — | — | 1 | - |
| CHEMBL1185460 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1800346 | — | Ki | = | 1.862 | nM | 8.73 |
| CHEMBL447183 | — | IC50 | = | 37.15 | nM | 7.43 |
| CHEMBL1800534 | — | IC50 | = | 38.9 | nM | 7.41 |
| CHEMBL1800533 | — | IC50 | = | 54.95 | nM | 7.26 |
| CHEMBL1800347 | — | IC50 | = | 70.79 | nM | 7.15 |
| CHEMBL1738840 | — | IC50 | = | 81.28 | nM | 7.09 |
| CHEMBL59925 | — | IC50 | = | 109.65 | nM | 6.96 |
| CHEMBL1800348 | — | IC50 | = | 114.82 | nM | 6.94 |
| CHEMBL1800528 | — | IC50 | = | 144.54 | nM | 6.84 |
| CHEMBL1800523 | — | IC50 | = | 154.88 | nM | 6.81 |
| CHEMBL1800526 | — | IC50 | = | 186.21 | nM | 6.73 |
| CHEMBL1800527 | — | IC50 | = | 380.19 | nM | 6.42 |
| CHEMBL1800531 | — | IC50 | = | 512.86 | nM | 6.29 |
| CHEMBL1800532 | — | IC50 | = | 724.44 | nM | 6.14 |
| CHEMBL1800530 | — | IC50 | = | 776.25 | nM | 6.11 |
| CHEMBL114551 | GW-274150 | IC50 | = | 1412.54 | nM | 5.85 |
| CHEMBL1800529 | — | IC50 | = | 2290.87 | nM | 5.64 |
| CHEMBL7889 | L-NIL | IC50 | = | 4677.35 | nM | 5.33 |
| CHEMBL51478 | — | IC50 | = | 10715.19 | nM | 4.97 |
| CHEMBL1800349 | — | IC50 | = | 48977.88 | nM | 4.31 |
| CHEMBL1800524 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1800525 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1185460 | — | IC50 | > | 100000.0 | nM | - |