Assay Detail
Functional
CHEMBL1804010
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Cytotoxicity against human H460 cells after 72 hrs by MTS assay
14
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.41 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1801950 | — | — | 1 | 5.92 |
| CHEMBL1077979 | — | — | 1 | 5.92 |
| CHEMBL1801948 | — | — | 1 | 5.39 |
| CHEMBL471474 | HYPOTHEMYCIN | — | 1 | 5.37 |
| CHEMBL491510 | TALERANOL | 2.0 | 2 | 5.02 |
| CHEMBL1099228 | ZEAENOL | — | 1 | - |
| CHEMBL1801949 | — | — | 1 | - |
| CHEMBL1801951 | — | — | 1 | - |
| CHEMBL454173 | ZEARALENONE | — | 1 | - |
| CHEMBL491499 | ZEARALANONE | — | 1 | - |
| CHEMBL450613 | ZERANOL | 2.0 | 1 | - |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | - |
| CHEMBL555196 | SILVESTROL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1801950 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1077979 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1801948 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL471474 | HYPOTHEMYCIN | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL491510 | TALERANOL | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL491510 | TALERANOL | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL1099228 | ZEAENOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL1801949 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1801951 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL454173 | ZEARALENONE | IC50 | > | 25000.0 | nM | - |
| CHEMBL491499 | ZEARALANONE | IC50 | > | 25000.0 | nM | - |
| CHEMBL450613 | ZERANOL | IC50 | > | 50000.0 | nM | - |
| CHEMBL65 | CAMPTOTHECIN | IC50 | < | 40.0 | nM | - |
| CHEMBL555196 | SILVESTROL | IC50 | - | — | - |