Assay Detail
Functional
CHEMBL1804015
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Antimalarial activity against Plasmodium falciparum NF54
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial pyrido[1,2-a]benzimidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.58 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.30 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.22 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 7.89 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 7.72 |
| CHEMBL584457 | — | — | 1 | 7.28 |
| CHEMBL1800623 | — | — | 1 | 7.28 |
| CHEMBL1802544 | — | — | 1 | 6.96 |
| CHEMBL1800559 | — | — | 1 | 6.96 |
| CHEMBL1800564 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL584457 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1800623 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL1802544 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1800559 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1800564 | — | IC50 | - | — | - |