Assay Detail
Binding
CHEMBL1804152
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Inhibition of NFkappa p65 isolated from nuclear extract of human HeLa cells by ELISA
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.20 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438139 | ROCAGLAMIDE | — | 1 | 7.12 |
| CHEMBL1077979 | — | — | 1 | 6.60 |
| CHEMBL1801948 | — | — | 1 | 6.12 |
| CHEMBL1801950 | — | — | 1 | 4.94 |
| CHEMBL1099228 | ZEAENOL | — | 1 | - |
| CHEMBL1801949 | — | — | 1 | - |
| CHEMBL1801951 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438139 | ROCAGLAMIDE | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL1077979 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1801948 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL1801950 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL1099228 | ZEAENOL | IC50 | > | 50000.0 | nM | - |
| CHEMBL1801949 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1801951 | — | IC50 | > | 50000.0 | nM | - |