Assay Detail
Binding
CHEMBL1804240
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant GST-tagged CLK1 using GRSRSRSRSRSR as substrate
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK1 (CHEMBL4224) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.45 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1802410 | — | — | 1 | 7.58 |
| CHEMBL1802406 | — | — | 1 | 7.52 |
| CHEMBL1802966 | — | — | 1 | 7.50 |
| CHEMBL1802405 | — | — | 1 | 7.39 |
| CHEMBL1802967 | — | — | 1 | 7.38 |
| CHEMBL1802963 | — | — | 1 | 7.19 |
| CHEMBL1802404 | — | — | 1 | 7.17 |
| CHEMBL1802401 | — | — | 1 | 7.16 |
| CHEMBL1802409 | — | — | 1 | 7.10 |
| CHEMBL1802391 | — | — | 1 | 7.06 |
| CHEMBL1802403 | — | — | 1 | 6.92 |
| CHEMBL46440 | MERIDIANIN D | — | 1 | 6.92 |
| CHEMBL1802965 | — | — | 1 | 6.75 |
| CHEMBL44541 | MERIDIANIN C | — | 1 | 6.66 |
| CHEMBL1802400 | — | — | 1 | 6.42 |
| CHEMBL1802971 | — | — | 1 | 6.42 |
| CHEMBL48082 | — | — | 1 | 6.28 |
| CHEMBL1802390 | — | — | 1 | 6.28 |
| CHEMBL1802408 | — | — | 1 | 6.21 |
| CHEMBL1802389 | — | — | 1 | 6.12 |
| CHEMBL1802399 | — | — | 1 | 6.06 |
| CHEMBL1802407 | — | — | 1 | 6.00 |
| CHEMBL1802396 | — | — | 1 | 5.89 |
| CHEMBL1802392 | — | — | 1 | 5.89 |
| CHEMBL1802962 | — | — | 1 | 5.85 |
| CHEMBL1802968 | — | — | 1 | 5.82 |
| CHEMBL1802395 | — | — | 1 | 5.82 |
| CHEMBL1802969 | — | — | 1 | 5.80 |
| CHEMBL1802970 | — | — | 1 | 5.75 |
| CHEMBL1802964 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1802410 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1802406 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1802966 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1802405 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1802967 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1802963 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1802404 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1802401 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1802409 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1802391 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL1802403 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL46440 | MERIDIANIN D | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1802965 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL44541 | MERIDIANIN C | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1802971 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1802400 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL48082 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL1802390 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL1802408 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL1802389 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL1802399 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL1802407 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1802396 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1802392 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1802962 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1802968 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1802395 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1802969 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1802970 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1802964 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1802398 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1802397 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1802402 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL1802972 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802393 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802394 | — | IC50 | > | 10000.0 | nM | - |