Assay Detail
Functional
CHEMBL1804651
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Cytotoxicity against human SH-SY5Y cells assessed as cell viability after 48 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.33 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.64 |
| CHEMBL1800905 | — | — | 1 | 8.62 |
| CHEMBL1800907 | — | — | 1 | 8.03 |
| CHEMBL1800904 | — | — | 1 | 7.55 |
| CHEMBL1800906 | — | — | 1 | 7.47 |
| CHEMBL1800908 | — | — | 1 | 7.43 |
| CHEMBL1800903 | — | — | 1 | 7.10 |
| CHEMBL1800604 | — | — | 1 | 6.51 |
| CHEMBL1800620 | — | — | 1 | 6.48 |
| CHEMBL1800602 | — | — | 1 | 6.46 |
| CHEMBL1800902 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1800905 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL1800907 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL1800904 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1800906 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1800908 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1800903 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL1800604 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1800620 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1800602 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1800902 | — | IC50 | = | 480.0 | nM | 6.32 |