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Assay Detail

CHEMBL1804677

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Binding
Inhibition of ASIC1a
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Acid-sensing ion channel 1 (CHEMBL1628477)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of non-amidine inhibitors of acid-sensing ion channel-3 (ASIC3).
Kuduk SD, Chang RK, Di Marco CN, Dipardo RM, Cook SP, Cato MJ, Jovanovska A, Urban MO, Leitl M, Spencer RH, Kane SA, Hartman GD, Bilodeau MT.
Bioorg Med Chem Lett (2011) 21 : 4255 -4258
PubMed 21669528 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.65 6.65

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1800430 1 6.65

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1800430 IC50 = 224.0 nM 6.65