Acid-sensing ion channel 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P78348. Use UniProt P78348 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P78348 as the stable identity anchor, then attach disease evidence before program review.
Acid-sensing ion channel 1
Review this target as Acid-sensing ion channel 1, mapped to UniProt P78348. Sequence length is 528 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Acid-sensing ion channel 1 as ChEMBL target CHEMBL1628477, mapped to UniProt P78348. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Acid-sensing ion channel 1 is the right protein anchor across sources, using UniProt P78348 as the stable mapping.
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| Preferred Name | Acid-sensing ion channel 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P78348 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Acid-sensing ion channel 1 |
| UniProt Accession | P78348 |
| Component Type | Protein |
| Sequence Length | 528 aa |
Acid-sensing ion channel 1
Review this target as Acid-sensing ion channel 1, mapped to UniProt P78348. Sequence length is 528 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3577296 | 7.56 | IC50 | 27.35 | Preclinical |
| CHEMBL1800430 | 6.65 | IC50 | 224.0 | Preclinical |
| CHEMBL5269133 | 6.39 | IC50 | 407.0 | Preclinical |
| CHEMBL5270983 | 6.29 | IC50 | 518.0 | Preclinical |
| CHEMBL5289168 | 6.14 | IC50 | 729.0 | Preclinical |
| CHEMBL5278611 | 6.01 | IC50 | 972.0 | Preclinical |
| CHEMBL5287933 | 5.85 | IC50 | 1420.0 | Preclinical |
| CHEMBL5285672 | 5.7 | IC50 | 1990.0 | Preclinical |
| CHEMBL5291421 | 5.7 | IC50 | 1990.0 | Preclinical |
| CHEMBL5267130 | 5.59 | IC50 | 2590.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 28 | 12 | 5.9 |
| single protein format | 3 | 1 | 6.7 |