Compound Detail
CHEMBL5278611
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Br.Br.C(=N\NC1=NCCN1)\c1ccc(-c2cc(-c3ccc(/C=N/NC4=NCCN4)cc3)[nH]n2)cc1
Basic Information
| ChEMBL ID | CHEMBL5278611 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SMPVWRQSCGXQRV-AIAMJZJGSA-N |
| Parent Compound | CHEMBL5315864 |
| Active Moiety | CHEMBL5315864 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
440.5
MW (Da)
1.51
ALogP
9
HBA
5
HBD
126.2
PSA (Ų)
0.29
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.01
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Acid-sensing ion channel 1 CHEMBL1628477 | IC50 | 6.01 | 6.01 | 972.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Acid-sensing ion channel 1 | IC50 | = | 972.0 | nM | 6.01 | Inhibition of human ASIC1a in HEK293 cells assessed as inward proton-gated curre... | 34097384 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34097384 | 10.1021/acs.jmedchem.1c00305 | Acid-sensing ion channel 1 | 2 |
| 34097384 | 10.1021/acs.jmedchem.1c00305 | Mus musculus | 2 |
| 34097384 | 10.1021/acs.jmedchem.1c00305 | Acid-sensing ion channel 2 | 1 |
| 34097384 | 10.1021/acs.jmedchem.1c00305 | Cortical neurone | 1 |
Data from ChEMBL 36 via Core Engine