Assay Detail
Binding
CHEMBL1805489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human QR2 expressed in Escherichia coli BL21 (DE3) using MTT and NMeH as substrate assessed as formazan formation
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ribosyldihydronicotinamide dehydrogenase [quinone] (CHEMBL3959) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from Streptomyces species, strain CNS284.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.32 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1802205 | — | — | 1 | 6.80 |
| CHEMBL1802199 | — | — | 1 | 6.73 |
| CHEMBL1802264 | — | — | 1 | 6.50 |
| CHEMBL1802260 | — | — | 1 | 6.35 |
| CHEMBL1802271 | — | — | 1 | 6.32 |
| CHEMBL1802203 | — | — | 1 | 6.16 |
| CHEMBL1802258 | — | — | 1 | 5.85 |
| CHEMBL1802277 | — | — | 1 | 5.54 |
| CHEMBL1802261 | — | — | 1 | 5.48 |
| CHEMBL1802272 | — | — | 1 | 5.46 |
| CHEMBL1802270 | — | — | 1 | 5.39 |
| CHEMBL1802267 | — | — | 1 | 5.32 |
| CHEMBL1802266 | — | — | 1 | 4.98 |
| CHEMBL1802269 | — | — | 1 | 4.95 |
| CHEMBL1802273 | BENZO[B]PHENAZINE | — | 1 | 4.95 |
| CHEMBL1379740 | — | — | 1 | 4.93 |
| CHEMBL1802259 | — | — | 1 | 4.87 |
| CHEMBL1420181 | — | — | 1 | 4.82 |
| CHEMBL1802263 | — | — | 1 | 4.74 |
| CHEMBL1802200 | — | — | 1 | 4.73 |
| CHEMBL1802202 | — | — | 1 | 4.57 |
| CHEMBL1802197 | — | — | 1 | 4.51 |
| CHEMBL1802265 | — | — | 1 | 4.45 |
| CHEMBL1802201 | — | — | 1 | 4.43 |
| CHEMBL1802262 | — | — | 1 | 4.22 |
| CHEMBL1802196 | — | — | 1 | - |
| CHEMBL1802268 | — | — | 1 | - |
| CHEMBL1802204 | — | — | 1 | - |
| CHEMBL1802198 | — | — | 1 | - |
| CHEMBL1802274 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1802205 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1802199 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL1802264 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1802260 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1802271 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1802203 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL1802258 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1802277 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1802261 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1802272 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1802270 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1802267 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL1802266 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL1802269 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL1802273 | BENZO[B]PHENAZINE | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL1379740 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL1802259 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL1420181 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL1802263 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL1802200 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL1802202 | — | IC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL1802197 | — | IC50 | = | 31100.0 | nM | 4.51 |
| CHEMBL1802265 | — | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL1802201 | — | IC50 | = | 36800.0 | nM | 4.43 |
| CHEMBL1802262 | — | IC50 | = | 60800.0 | nM | 4.22 |
| CHEMBL1802196 | — | IC50 | - | — | - | |
| CHEMBL1802268 | — | IC50 | - | — | - | |
| CHEMBL1802204 | — | IC50 | - | — | - | |
| CHEMBL1802198 | — | IC50 | - | — | - | |
| CHEMBL1802274 | — | IC50 | - | — | - | |
| CHEMBL1802275 | — | IC50 | - | — | - | |
| CHEMBL1802276 | — | IC50 | - | — | - |