Assay Detail
Binding
CHEMBL1805659
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Binding affinity to progesterone receptor by fluorescence polarization assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dimethyl-diphenyl-propanamide derivatives as nonsteroidal dissociated glucocorticoid receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.16 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1800984 | — | — | 1 | 7.66 |
| CHEMBL1801006 | — | — | 1 | 7.51 |
| CHEMBL1801008 | — | — | 1 | 7.28 |
| CHEMBL1800985 | — | — | 1 | 7.28 |
| CHEMBL1800981 | — | — | 1 | 7.26 |
| CHEMBL1800983 | — | — | 1 | 6.85 |
| CHEMBL1801005 | — | — | 1 | 6.84 |
| CHEMBL1801012 | — | — | 1 | 6.56 |
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1800984 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL1801006 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL1801008 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL1800985 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL1800981 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL1800983 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL1801005 | — | Ki | = | 144.0 | nM | 6.84 |
| CHEMBL1801012 | — | Ki | = | 273.0 | nM | 6.56 |
| CHEMBL131 | PREDNISOLONE | Ki | > | 6000.0 | nM | - |