Assay Detail
Functional
CHEMBL1805720
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anesthetic effect on prelimb-bud stage of Xenopus laevis tadpole assessed as loss of righting reflex
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Xenopus laevis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.02 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1801469 | — | — | 1 | 6.14 |
| CHEMBL1801470 | — | — | 1 | 5.98 |
| CHEMBL190279 | ALFAXALONE | 2.0 | 1 | 5.95 |
| CHEMBL1801468 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1801469 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1801470 | — | EC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL190279 | ALFAXALONE | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL1801468 | — | EC50 | > | 10000.0 | nM | - |