Assay Detail
Binding
CHEMBL1806216
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human NPP1 expressed in COS7 cells assessed as enzyme-substrate-inhibitor dissociation constant using pnp-TMP as the substrate after 15 mins by malachite green reagent method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (CHEMBL5925) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Diadenosine 5',5''-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.31 | 4.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1802094 | — | — | 1 | 4.51 |
| CHEMBL1802097 | — | — | 1 | 4.10 |
| CHEMBL1802095 | — | — | 1 | - |
| CHEMBL1802096 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1802094 | — | Ki | = | 31000.0 | nM | 4.51 |
| CHEMBL1802097 | — | Ki | = | 80000.0 | nM | 4.10 |
| CHEMBL1802095 | — | Ki | = | 145000.0 | nM | - |
| CHEMBL1802096 | — | Ki | = | 147000.0 | nM | - |