Assay Detail
Binding
CHEMBL1806340
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Inhibition of PTP1B expressed in Escherichia coli assessed as p-nitrophenol release from pNPP substrate preincubated for 10 mins
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel thiazolidinedione derivatives with anti-obesity effects: dual action as PTP1B inhibitors and PPAR-γ activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.16 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1801440 | — | — | 1 | 5.89 |
| CHEMBL1801411 | — | — | 1 | 5.85 |
| CHEMBL1801439 | — | — | 1 | 5.70 |
| CHEMBL1801434 | — | — | 1 | 5.64 |
| CHEMBL1801404 | — | — | 1 | 5.40 |
| CHEMBL1801407 | — | — | 1 | 5.40 |
| CHEMBL1801435 | — | — | 1 | 5.22 |
| CHEMBL1801409 | — | — | 1 | 5.22 |
| CHEMBL1801402 | — | — | 1 | 5.10 |
| CHEMBL1801406 | — | — | 1 | 5.05 |
| CHEMBL1801405 | — | — | 1 | 5.05 |
| CHEMBL1801401 | — | — | 1 | 5.05 |
| CHEMBL1801400 | — | — | 1 | 5.00 |
| CHEMBL1801437 | — | — | 1 | 4.96 |
| CHEMBL1801432 | — | — | 1 | 4.92 |
| CHEMBL1801433 | — | — | 1 | 4.92 |
| CHEMBL1801438 | — | — | 1 | 4.85 |
| CHEMBL1801403 | — | — | 1 | 4.80 |
| CHEMBL1801410 | — | — | 1 | 4.72 |
| CHEMBL1801436 | — | — | 1 | 4.48 |
| CHEMBL1801408 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1801440 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1801411 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1801439 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1801434 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1801404 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1801407 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1801435 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1801409 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1801402 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1801406 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1801405 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1801401 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1801400 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1801437 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1801432 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1801433 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1801438 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1801403 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1801410 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL1801436 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL1801408 | — | IC50 | = | 136000.0 | nM | - |