Assay Detail
Binding
CHEMBL1809348
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Inhibition of Herpes simplex virus-1 thymidine kinase-mediated phosphorylation of [methyl-3H]dThd at 1 uM after 30 mins by scintillation counting
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human alphaherpesvirus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.20 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1807156 | — | — | 1 | 5.55 |
| CHEMBL1807153 | — | — | 1 | 5.46 |
| CHEMBL1807154 | — | — | 1 | 5.12 |
| CHEMBL1807155 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1807156 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1807153 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1807154 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL1807155 | — | IC50 | = | 22000.0 | nM | 4.66 |