Assay Detail
ADMET
CHEMBL1809437
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferation activity against mouse L1210 cells after 2 days by coulter counter
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.47 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1807159 | — | — | 1 | 4.64 |
| CHEMBL1807161 | — | — | 1 | 4.30 |
| CHEMBL1807162 | — | — | 1 | - |
| CHEMBL1807160 | — | — | 1 | - |
| CHEMBL1807158 | — | — | 1 | - |
| CHEMBL1807156 | — | — | 1 | - |
| CHEMBL1807154 | — | — | 1 | - |
| CHEMBL1807155 | — | — | 1 | - |
| CHEMBL1807153 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1807159 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1807161 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1807162 | — | IC50 | = | 175000.0 | nM | - |
| CHEMBL1807160 | — | IC50 | = | 134000.0 | nM | - |
| CHEMBL1807158 | — | IC50 | = | 226000.0 | nM | - |
| CHEMBL1807156 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL1807154 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL1807155 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL1807153 | — | IC50 | = | 302000.0 | nM | - |