Assay Detail
ADMET
CHEMBL1809440
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Antiproliferation activity against human HeLa cells after 3 days by coulter counter
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.54 | 4.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1807159 | — | — | 1 | 4.54 |
| CHEMBL1807162 | — | — | 1 | - |
| CHEMBL1807161 | — | — | 1 | - |
| CHEMBL1807160 | — | — | 1 | - |
| CHEMBL1807158 | — | — | 1 | - |
| CHEMBL1807156 | — | — | 1 | - |
| CHEMBL1807155 | — | — | 1 | - |
| CHEMBL1807153 | — | — | 1 | - |
| CHEMBL1807154 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1807159 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL1807162 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL1807161 | — | IC50 | = | 148000.0 | nM | - |
| CHEMBL1807160 | — | IC50 | = | 133000.0 | nM | - |
| CHEMBL1807158 | — | IC50 | = | 126000.0 | nM | - |
| CHEMBL1807156 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL1807155 | — | IC50 | >= | 500000.0 | nM | - |
| CHEMBL1807153 | — | IC50 | = | 230000.0 | nM | - |
| CHEMBL1807154 | — | IC50 | = | 458000.0 | nM | - |