Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1809469

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human NTUB1 cells after 72 hrs by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NTUB1
Confidence 1 — Organism
Curated By Autocuration

Publication

18β-Glycyrrhetinic acid derivatives induced mitochondrial-mediated apoptosis through reactive oxygen species-mediated p53 activation in NTUB1 cells.
Lin KW, Huang AM, Hour TC, Yang SC, Pu YS, Lin CN.
Bioorg Med Chem (2011) 19 : 4274 -4285
PubMed 21696969 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 4.70 5.63

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL450589 1 5.63
CHEMBL446812 1 5.48
CHEMBL1807181 1 5.32
CHEMBL508447 1 5.03
CHEMBL1807179 1 4.89
CHEMBL508226 1 4.88
CHEMBL1807182 1 4.80
CHEMBL494341 1 4.76
CHEMBL1807172 1 4.74
CHEMBL493512 1 4.73
CHEMBL1807177 1 4.71
CHEMBL1807166 1 4.69
CHEMBL493952 1 4.68
CHEMBL492918 1 4.62
CHEMBL1807169 1 4.60
CHEMBL1807176 1 4.59
CHEMBL1807171 1 4.56
CHEMBL230006 ENOXOLONE 2.0 1 4.56
CHEMBL1807178 1 4.54
CHEMBL1807175 1 4.52
CHEMBL1807170 1 4.50
CHEMBL1807173 1 4.37
CHEMBL1807174 1 4.31
CHEMBL1807165 1 4.25
CHEMBL1807168 1 4.24
CHEMBL1807167 1 4.13
CHEMBL1807180 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL450589 IC50 = 2340.0 nM 5.63
CHEMBL446812 IC50 = 3310.0 nM 5.48
CHEMBL1807181 IC50 = 4760.0 nM 5.32
CHEMBL508447 IC50 = 9410.0 nM 5.03
CHEMBL1807179 IC50 = 12750.0 nM 4.89
CHEMBL508226 IC50 = 13120.0 nM 4.88
CHEMBL1807182 IC50 = 15950.0 nM 4.80
CHEMBL494341 IC50 = 17470.0 nM 4.76
CHEMBL1807172 IC50 = 18200.0 nM 4.74
CHEMBL493512 IC50 = 18570.0 nM 4.73
CHEMBL1807177 IC50 = 19440.0 nM 4.71
CHEMBL1807166 IC50 = 20230.0 nM 4.69
CHEMBL493952 IC50 = 20720.0 nM 4.68
CHEMBL492918 IC50 = 24280.0 nM 4.62
CHEMBL1807169 IC50 = 25300.0 nM 4.60
CHEMBL1807176 IC50 = 25660.0 nM 4.59
CHEMBL1807171 IC50 = 27760.0 nM 4.56
CHEMBL230006 ENOXOLONE IC50 = 27310.0 nM 4.56
CHEMBL1807178 IC50 = 29170.0 nM 4.54
CHEMBL1807175 IC50 = 30120.0 nM 4.52
CHEMBL1807170 IC50 = 31350.0 nM 4.50
CHEMBL1807173 IC50 = 42740.0 nM 4.37
CHEMBL1807174 IC50 = 49390.0 nM 4.31
CHEMBL1807165 IC50 = 56500.0 nM 4.25
CHEMBL1807168 IC50 = 57610.0 nM 4.24
CHEMBL1807167 IC50 = 73540.0 nM 4.13
CHEMBL1807180 IC50 > 50000.0 nM -