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Assay Detail

CHEMBL1809786

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production treated 1 hr before LPS challenge measured after 24 hrs by EIA
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type RAW264.7
Confidence 1 — Organism
Curated By Autocuration

Target

RAW264.7 (CHEMBL612557)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis of aurones and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells.
Shin SY, Shin MC, Shin JS, Lee KT, Lee YS.
Bioorg Med Chem Lett (2011) 21 : 4520 -4523
PubMed 21723122 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.19 5.97

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL426110 1 5.97
CHEMBL1807488 1 5.78
CHEMBL1172318 1 5.75
CHEMBL1171364 1 5.70
CHEMBL1807489 1 5.65
CHEMBL1807495 1 5.60
CHEMBL1807487 1 5.54
CHEMBL1171363 1 5.42
CHEMBL1807493 1 5.31
CHEMBL490355 SULFURETIN 1 5.23
CHEMBL1807492 1 5.06
CHEMBL1172319 1 5.03
CHEMBL1807490 1 4.88
CHEMBL1171175 1 4.74
CHEMBL1807311 1 4.73
CHEMBL1807491 1 4.45
CHEMBL1807486 1 4.42
CHEMBL1807494 1 4.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL426110 IC50 = 1060.0 nM 5.97
CHEMBL1807488 IC50 = 1670.0 nM 5.78
CHEMBL1172318 IC50 = 1800.0 nM 5.75
CHEMBL1171364 IC50 = 2000.0 nM 5.70
CHEMBL1807489 IC50 = 2220.0 nM 5.65
CHEMBL1807495 IC50 = 2500.0 nM 5.60
CHEMBL1807487 IC50 = 2900.0 nM 5.54
CHEMBL1171363 IC50 = 3790.0 nM 5.42
CHEMBL1807493 IC50 = 4900.0 nM 5.31
CHEMBL490355 SULFURETIN IC50 = 5900.0 nM 5.23
CHEMBL1807492 IC50 = 8800.0 nM 5.06
CHEMBL1172319 IC50 = 9300.0 nM 5.03
CHEMBL1807490 IC50 = 13150.0 nM 4.88
CHEMBL1171175 IC50 = 18100.0 nM 4.74
CHEMBL1807311 IC50 = 18620.0 nM 4.73
CHEMBL1807491 IC50 = 35820.0 nM 4.45
CHEMBL1807486 IC50 = 37620.0 nM 4.42
CHEMBL1807494 IC50 = 59500.0 nM 4.22