Assay Detail
Functional
CHEMBL1810018
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Cytotoxicity against human HCT116 cells after 4 days by MTT assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Chemistry of ecteinascidins. Part 3: preparation of 2'-N-acyl derivatives of ecteinascidin 770 and evaluation of cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 8.24 | 10.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1808822 | — | — | 1 | 10.35 |
| CHEMBL1808826 | — | — | 1 | 10.35 |
| CHEMBL1808829 | — | — | 1 | 10.28 |
| CHEMBL1808824 | — | — | 1 | 10.17 |
| CHEMBL1808825 | — | — | 1 | 10.07 |
| CHEMBL1808823 | — | — | 1 | 9.89 |
| CHEMBL1808821 | — | — | 1 | 9.85 |
| CHEMBL1808803 | — | — | 1 | 9.80 |
| CHEMBL1808819 | — | — | 1 | 9.43 |
| CHEMBL1808820 | — | — | 1 | 9.42 |
| CHEMBL1808808 | — | — | 1 | 9.35 |
| CHEMBL1808807 | — | — | 1 | 9.30 |
| CHEMBL1808830 | — | — | 1 | 9.22 |
| CHEMBL448144 | ECTEINASCIDIN 770 | — | 1 | 9.22 |
| CHEMBL1808805 | — | — | 1 | 8.62 |
| CHEMBL1808831 | — | — | 1 | 8.57 |
| CHEMBL1808804 | — | — | 1 | 7.27 |
| CHEMBL1808816 | — | — | 1 | 6.82 |
| CHEMBL1808811 | — | — | 1 | 6.75 |
| CHEMBL1808809 | — | — | 1 | 6.72 |
| CHEMBL1808810 | — | — | 1 | 6.58 |
| CHEMBL1808812 | — | — | 1 | 6.55 |
| CHEMBL1808814 | — | — | 1 | 6.51 |
| CHEMBL1808815 | — | — | 1 | 6.50 |
| CHEMBL1808813 | — | — | 1 | 6.41 |
| CHEMBL1808817 | — | — | 1 | 6.32 |
| CHEMBL1808828 | — | — | 1 | 6.28 |
| CHEMBL1808806 | — | — | 1 | 6.21 |
| CHEMBL1808827 | — | — | 1 | 6.20 |
| CHEMBL1808818 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1808822 | — | IC50 | = | 0.045 | nM | 10.35 |
| CHEMBL1808826 | — | IC50 | = | 0.045 | nM | 10.35 |
| CHEMBL1808829 | — | IC50 | = | 0.053 | nM | 10.28 |
| CHEMBL1808824 | — | IC50 | = | 0.067 | nM | 10.17 |
| CHEMBL1808825 | — | IC50 | = | 0.086 | nM | 10.07 |
| CHEMBL1808823 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL1808821 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL1808803 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL1808819 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL1808820 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL1808808 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL1808807 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1808830 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL448144 | ECTEINASCIDIN 770 | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1808805 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL1808831 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL1808804 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1808816 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1808811 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1808809 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1808810 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1808812 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1808814 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1808815 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1808813 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1808817 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1808828 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL1808806 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL1808827 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL1808818 | — | IC50 | > | 1000.0 | nM | - |