Assay Detail
Binding
CHEMBL1810157
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Inhibition of recombinant MET using biotinylated-poly(GT) peptide as substrate after 60 mins
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of an aryloxy oxo pyrimidinone library that displays ALK-selective inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 7.26 | 9.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 9.11 |
| CHEMBL1807757 | — | — | 1 | 5.40 |
| CHEMBL1807761 | — | — | 1 | - |
| CHEMBL1807760 | — | — | 1 | - |
| CHEMBL1807759 | — | — | 1 | - |
| CHEMBL1807758 | — | — | 1 | - |
| CHEMBL1807768 | — | — | 1 | - |
| CHEMBL1808226 | — | — | 1 | - |
| CHEMBL1808225 | — | — | 1 | - |
| CHEMBL1808224 | — | — | 1 | - |
| CHEMBL1808223 | — | — | 1 | - |
| CHEMBL1808222 | — | — | 1 | - |
| CHEMBL1808221 | — | — | 1 | - |
| CHEMBL1808220 | — | — | 1 | - |
| CHEMBL1806514 | — | — | 1 | - |
| CHEMBL1808108 | — | — | 1 | - |
| CHEMBL1808107 | — | — | 1 | - |
| CHEMBL1808106 | — | — | 1 | - |
| CHEMBL1808093 | — | — | 1 | - |
| CHEMBL1808104 | — | — | 1 | - |
| CHEMBL1808103 | — | — | 1 | - |
| CHEMBL1808102 | — | — | 1 | - |
| CHEMBL1808101 | — | — | 1 | - |
| CHEMBL1808100 | — | — | 1 | - |
| CHEMBL1808099 | — | — | 1 | - |
| CHEMBL1808098 | — | — | 1 | - |
| CHEMBL1808097 | — | — | 1 | - |
| CHEMBL1808096 | — | — | 1 | - |
| CHEMBL1808095 | — | — | 1 | - |
| CHEMBL1808105 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL1807757 | — | IC50 | = | 4010.0 | nM | 5.40 |
| CHEMBL1807768 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808092 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1807758 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1807759 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1807760 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1807761 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1807762 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1807763 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1807764 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1807765 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1807766 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1807767 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808094 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1807769 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1807770 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1807771 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1807772 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808087 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808088 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808089 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808090 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808091 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808093 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808105 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808095 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808096 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808097 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808098 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808099 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808100 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808101 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808102 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808103 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808104 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808226 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808106 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808107 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808108 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1806514 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808220 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808221 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808222 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808223 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808224 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1808225 | — | IC50 | > | 40000.0 | nM | - |