Assay Detail
Functional
CHEMBL1810299
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Growth inhibition of human PC3 cells after 72 hrs
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of 2-oxatriazines as highly potent pan-PI3K/mTOR dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.36 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1808977 | — | — | 1 | 8.05 |
| CHEMBL1808988 | — | — | 1 | 7.96 |
| CHEMBL592445 | GEDATOLISIB | 3.0 | 1 | 7.96 |
| CHEMBL1808986 | — | — | 1 | 7.89 |
| CHEMBL1808989 | — | — | 1 | 7.75 |
| CHEMBL589258 | — | — | 1 | 7.68 |
| CHEMBL1808991 | — | — | 1 | 7.68 |
| CHEMBL1808990 | — | — | 1 | 7.57 |
| CHEMBL1808984 | — | — | 1 | 7.50 |
| CHEMBL1808985 | — | — | 1 | 7.48 |
| CHEMBL1808979 | — | — | 1 | 7.47 |
| CHEMBL1808987 | — | — | 1 | 7.39 |
| CHEMBL1808978 | — | — | 1 | 7.16 |
| CHEMBL1808980 | — | — | 1 | 7.15 |
| CHEMBL1808982 | — | — | 1 | 7.04 |
| CHEMBL1808983 | — | — | 1 | 6.96 |
| CHEMBL1808981 | — | — | 1 | 6.43 |
| CHEMBL1808992 | — | — | 1 | 5.35 |
| CHEMBL1808993 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1808977 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1808988 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL592445 | GEDATOLISIB | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1808986 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1808989 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL589258 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1808991 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1808990 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1808984 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1808985 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1808979 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1808987 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1808978 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL1808980 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL1808982 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL1808983 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL1808981 | — | IC50 | = | 374.0 | nM | 6.43 |
| CHEMBL1808992 | — | IC50 | = | 4453.0 | nM | 5.35 |
| CHEMBL1808993 | — | IC50 | > | 1000.0 | nM | - |