Assay Detail
Functional
CHEMBL1810396
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Cytotoxicity against multidrug-resistant human A2780AD cells overexpressing p-gp after 48 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 ADR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Effects of C7 substitutions in a high affinity microtubule-binding taxane on antitumor activity and drug transport.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.23 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1809080 | — | — | 1 | 7.85 |
| CHEMBL1809086 | — | — | 1 | 6.77 |
| CHEMBL1809081 | — | — | 1 | 6.53 |
| CHEMBL1809084 | — | — | 1 | 6.15 |
| CHEMBL1809083 | — | — | 1 | 6.06 |
| CHEMBL1809088 | — | — | 1 | 6.02 |
| CHEMBL1809085 | — | — | 1 | 5.89 |
| CHEMBL1809087 | — | — | 1 | 5.85 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.72 |
| CHEMBL1809082 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1809080 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1809086 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1809081 | — | IC50 | = | 293.0 | nM | 6.53 |
| CHEMBL1809084 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL1809083 | — | IC50 | = | 875.0 | nM | 6.06 |
| CHEMBL1809088 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL1809085 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1809087 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1809082 | — | IC50 | = | 3200.0 | nM | 5.50 |