Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1810429

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of thrombin
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Prothrombin (CHEMBL204)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT.
Sielaff F, Böttcher-Friebertshäuser E, Meyer D, Saupe SM, Volk IM, Garten W, Steinmetzer T.
Bioorg Med Chem Lett (2011) 21 : 4860 -4864
PubMed 21741839 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 7.83 9.41

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1809213 1 9.41
CHEMBL1809216 1 9.00
CHEMBL1229259 1 8.46
CHEMBL1809238 1 8.28
CHEMBL1809214 1 8.17
CHEMBL1809239 1 8.01
CHEMBL1809241 1 7.87
CHEMBL1809250 1 7.54
CHEMBL1809252 1 7.18
CHEMBL1809251 1 7.17
CHEMBL1809254 1 7.13
CHEMBL1809256 1 5.79

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1809213 Ki = 0.39 nM 9.41
CHEMBL1809216 Ki = 1.0 nM 9.00
CHEMBL1229259 Ki = 3.5 nM 8.46
CHEMBL1809238 Ki = 5.2 nM 8.28
CHEMBL1809214 Ki = 6.7 nM 8.17
CHEMBL1809239 Ki = 9.8 nM 8.01
CHEMBL1809241 Ki = 13.5 nM 7.87
CHEMBL1809250 Ki = 29.0 nM 7.54
CHEMBL1809252 Ki = 66.0 nM 7.18
CHEMBL1809251 Ki = 68.0 nM 7.17
CHEMBL1809254 Ki = 74.0 nM 7.13
CHEMBL1809256 Ki = 1610.0 nM 5.79