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Assay Detail

CHEMBL1810449

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anticancer activity against human LNCAP cells after 24 hrs by MTT assay in presence of testosterone
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type LNCaP
Confidence 1 — Organism
Curated By Autocuration

Target

LNCaP (CHEMBL612518)
Type CELL-LINE
Organism Homo sapiens

Publication

Aldol derivatives of Thioxoimidazolidinones as potential anti-prostate cancer agents.
Khatik GL, Kaur J, Kumar V, Tikoo K, Venugopalan P, Nair VA.
Eur J Med Chem (2011) 46 : 3291 -3301
PubMed 21600678 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 32 4.84 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1806848 1 6.30
CHEMBL1806853 1 6.29
CHEMBL1807095 1 6.07
CHEMBL1806854 1 6.06
CHEMBL806 FLUTAMIDE 4.0 1 6.05
CHEMBL1806856 1 6.03
CHEMBL1806847 1 6.02
CHEMBL1806855 1 4.48
CHEMBL1807011 1 4.27
CHEMBL1807017 1 4.16
CHEMBL1806857 1 4.13
CHEMBL1807016 1 4.08
CHEMBL1806849 1 4.03
CHEMBL1807099 1 4.01
CHEMBL1806846 1 4.00
CHEMBL1806852 1 4.00
CHEMBL1806845 1 4.00
CHEMBL1806851 1 4.00
CHEMBL1806858 1 4.00
CHEMBL1807012 1 -
CHEMBL1807015 1 -
CHEMBL1807014 1 -
CHEMBL1807013 1 -
CHEMBL1806862 1 -
CHEMBL1806861 1 -
CHEMBL1806860 1 -
CHEMBL1806859 1 -
CHEMBL1806850 1 -
CHEMBL1807098 1 -
CHEMBL1807097 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1806848 IC50 = 500.0 nM 6.30
CHEMBL1806853 IC50 = 507.0 nM 6.29
CHEMBL1807095 IC50 = 860.0 nM 6.07
CHEMBL1806854 IC50 = 880.0 nM 6.06
CHEMBL806 FLUTAMIDE IC50 = 900.0 nM 6.05
CHEMBL1806856 IC50 = 939.0 nM 6.03
CHEMBL1806847 IC50 = 960.0 nM 6.02
CHEMBL1806855 IC50 = 33000.0 nM 4.48
CHEMBL1807011 IC50 = 54000.0 nM 4.27
CHEMBL1807017 IC50 = 70000.0 nM 4.16
CHEMBL1806857 IC50 = 73400.0 nM 4.13
CHEMBL1807016 IC50 = 84000.0 nM 4.08
CHEMBL1806849 IC50 = 93200.0 nM 4.03
CHEMBL1807099 IC50 = 98200.0 nM 4.01
CHEMBL1806846 IC50 = 100000.0 nM 4.00
CHEMBL1806845 IC50 = 100000.0 nM 4.00
CHEMBL1806851 IC50 = 100000.0 nM 4.00
CHEMBL1806852 IC50 = 100000.0 nM 4.00
CHEMBL1806858 IC50 = 100000.0 nM 4.00
CHEMBL1807012 IC50 - -
CHEMBL1807015 IC50 > 100000.0 nM -
CHEMBL1807014 IC50 > 100000.0 nM -
CHEMBL1807013 IC50 > 100000.0 nM -
CHEMBL1806862 IC50 > 100000.0 nM -
CHEMBL1806861 IC50 > 100000.0 nM -
CHEMBL1806860 IC50 > 100000.0 nM -
CHEMBL1806859 IC50 > 100000.0 nM -
CHEMBL1806850 IC50 > 100000.0 nM -
CHEMBL1807098 IC50 > 100000.0 nM -
CHEMBL1807097 IC50 > 100000.0 nM -
CHEMBL1807096 IC50 > 100000.0 nM -
CHEMBL53463 DOXORUBICIN IC50 - -