Assay Detail
Binding
CHEMBL1811057
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IGF1-induced autophosphorylation of human recombinant IGF1R expressed in mouse fibroblasts by high throughput assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.15 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1809194 | — | — | 1 | 8.05 |
| CHEMBL1809224 | — | — | 1 | 7.89 |
| CHEMBL1809225 | — | — | 1 | 7.89 |
| CHEMBL1809044 | — | — | 1 | 7.77 |
| CHEMBL1809198 | — | — | 1 | 7.66 |
| CHEMBL1809229 | — | — | 1 | 7.62 |
| CHEMBL1809204 | — | — | 1 | 7.60 |
| CHEMBL1809205 | — | — | 1 | 7.58 |
| CHEMBL1809199 | — | — | 1 | 7.42 |
| CHEMBL1809206 | — | — | 1 | 7.37 |
| CHEMBL1809222 | — | — | 1 | 7.30 |
| CHEMBL1809201 | — | — | 1 | 7.27 |
| CHEMBL1809196 | — | — | 1 | 7.24 |
| CHEMBL1809226 | — | — | 1 | 7.18 |
| CHEMBL1809227 | — | — | 1 | 7.15 |
| CHEMBL1809195 | — | — | 1 | 7.04 |
| CHEMBL1809200 | — | — | 1 | 6.96 |
| CHEMBL1809202 | — | — | 1 | 6.96 |
| CHEMBL1809193 | — | — | 1 | 6.89 |
| CHEMBL1809207 | — | — | 1 | 6.89 |
| CHEMBL1806525 | — | — | 1 | 6.77 |
| CHEMBL1809221 | — | — | 1 | 6.72 |
| CHEMBL1809197 | — | — | 1 | 6.72 |
| CHEMBL1809223 | — | — | 1 | 6.57 |
| CHEMBL1809228 | — | — | 1 | 6.57 |
| CHEMBL1809203 | — | — | 1 | 6.11 |
| CHEMBL1809192 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1809194 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1809224 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1809225 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1809044 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1809198 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1809229 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1809204 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1809205 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1809199 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1809206 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1809222 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1809201 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1809196 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL1809226 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1809227 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL1809195 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL1809200 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1809202 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1809193 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1809207 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1806525 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1809221 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1809197 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1809223 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1809228 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1809203 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL1809192 | — | IC50 | = | 1340.0 | nM | 5.87 |