Assay Detail
Functional
CHEMBL1811227
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Human cytomegalovirus strain AD169 assessed as reduction of virus induced cytopathicity by cell based assay
18
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: efficient synthesis and antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.21 | 6.10 |
| Activity | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 6.10 |
| CHEMBL1808675 | — | — | 1 | 6.03 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.23 |
| CHEMBL1808682 | — | — | 1 | 4.44 |
| CHEMBL1808677 | — | — | 1 | 4.23 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
| CHEMBL1808683 | — | — | 1 | - |
| CHEMBL1808678 | — | — | 1 | - |
| CHEMBL1808679 | — | — | 1 | - |
| CHEMBL1808680 | — | — | 1 | - |
| CHEMBL1808681 | — | — | 1 | - |
| CHEMBL1808676 | — | — | 1 | - |
| CHEMBL1808684 | — | — | 1 | - |
| CHEMBL1808685 | — | — | 1 | - |
| CHEMBL1808686 | — | — | 1 | - |
| CHEMBL1808687 | — | — | 1 | - |
| CHEMBL1808688 | — | — | 1 | - |
| CHEMBL1808689 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL1808675 | — | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1808682 | — | EC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL1808677 | — | EC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL184 | ACYCLOVIR | EC50 | - | — | - | |
| CHEMBL1808683 | — | EC50 | > | 361000.0 | nM | - |
| CHEMBL1808678 | — | EC50 | > | 315000.0 | nM | - |
| CHEMBL1808679 | — | EC50 | > | 240000.0 | nM | - |
| CHEMBL1808680 | — | EC50 | = | 165000.0 | nM | - |
| CHEMBL1808681 | — | EC50 | = | 188000.0 | nM | - |
| CHEMBL1808676 | — | EC50 | = | 159000.0 | nM | - |
| CHEMBL1808684 | — | Activity | - | — | - | |
| CHEMBL1808685 | — | Activity | - | — | - | |
| CHEMBL1808686 | — | Activity | - | — | - | |
| CHEMBL1808687 | — | Activity | - | — | - | |
| CHEMBL1808688 | — | Activity | - | — | - | |
| CHEMBL1808689 | — | Activity | - | — | - |