Assay Detail
Binding
CHEMBL1811515
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Inhibition of human cathepsin L using Z-Phe-Arg-AMC as substrate after 1 hr by fluorescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Azepanone-based inhibitors of human cathepsin S: optimization of selectivity via the P2 substituent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 9.15 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL194643 | — | — | 1 | 9.37 |
| CHEMBL284939 | — | — | 1 | 8.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL194643 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL284939 | — | Ki | = | 1.2 | nM | 8.92 |