Assay Detail
Binding
CHEMBL1811533
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Inhibition of B-Raf V600E mutant
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.16 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1808262 | — | — | 1 | 9.30 |
| CHEMBL1808255 | — | — | 1 | 9.22 |
| CHEMBL1808259 | — | — | 1 | 9.22 |
| CHEMBL1808256 | — | — | 1 | 9.10 |
| CHEMBL1808263 | — | — | 1 | 9.05 |
| CHEMBL1808261 | — | — | 1 | 8.92 |
| CHEMBL1808260 | — | — | 1 | 8.89 |
| CHEMBL1807711 | — | — | 1 | 8.44 |
| CHEMBL1808264 | — | — | 1 | 8.42 |
| CHEMBL1807709 | — | — | 1 | 8.40 |
| CHEMBL1807706 | — | — | 1 | 8.30 |
| CHEMBL1807707 | — | — | 1 | 8.05 |
| CHEMBL1808257 | — | — | 1 | 8.02 |
| CHEMBL1807710 | — | — | 1 | 7.92 |
| CHEMBL1807705 | — | — | 1 | 7.92 |
| CHEMBL1808258 | — | — | 1 | 7.47 |
| CHEMBL1807708 | — | — | 1 | 6.88 |
| CHEMBL1808254 | — | — | 1 | 5.87 |
| CHEMBL1807712 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1808262 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1808255 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1808259 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1808256 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1808263 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1808261 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1808260 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1807711 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL1808264 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL1807709 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1807706 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1807707 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1808257 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL1807710 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1807705 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1808258 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1807708 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL1808254 | — | IC50 | = | 1358.0 | nM | 5.87 |
| CHEMBL1807712 | — | IC50 | = | 1970.0 | nM | 5.71 |