Compound Detail
CHEMBL1807712
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CCc1nc(-c2cccc(N(C)S(=O)(=O)c3ccccc3)c2)c(-c2ccnc(Nc3ccc(N4CCN(C(C)=O)CC4)nc3)n2)s1
Basic Information
| ChEMBL ID | CHEMBL1807712 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DFNROAQMFQXLQW-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
654.8
MW (Da)
5.46
ALogP
10
HBA
1
HBD
124.5
PSA (Ų)
0.22
QED
2
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.33
IC50 1 meas. best 5.71
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase B-raf CHEMBL5145 | IC50 | 5.71 | 5.71 | 1970.0 | 1 |
| Serine/threonine-protein kinase B-raf CHEMBL5145 | EC50 | 5.33 | 5.33 | 4731.0 | 1 |
| SK-MEL-28 CHEMBL614919 | EC50 | 5.07 | 5.07 | 8619.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase B-raf | IC50 | = | 1970.0 | nM | 5.71 | Inhibition of B-Raf V600E mutant | 21733693 |
| Serine/threonine-protein kinase B-raf | EC50 | = | 4731.0 | nM | 5.33 | Inhibition of B-Raf V600E mutant in human SK-MEL-28 cells assessed as reduction ... | 21733693 |
| SK-MEL-28 | EC50 | = | 8619.0 | nM | 5.07 | Antiproliferative activity against human SK-MEL-28 cells expressing B-Raf V600E ... | 21733693 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21733693 | 10.1016/j.bmcl.2011.06.021 | Serine/threonine-protein kinase B-raf | 2 |
| 21733693 | 10.1016/j.bmcl.2011.06.021 | SK-MEL-28 | 1 |
| - | 10.6019/CHEMBL3988181 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine