Assay Detail
Binding
CHEMBL1815165
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Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled pBR322 DNA after 30 mins by agarose gel electrophoresis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.27 | 5.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1812144 | — | — | 1 | 5.81 |
| CHEMBL1812139 | — | — | 1 | 5.73 |
| CHEMBL1812137 | — | — | 1 | 5.31 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1812144 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL1812139 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL1812137 | — | IC50 | = | 4880.0 | nM | 5.31 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 60300.0 | nM | 4.22 |