Assay Detail
Functional
CHEMBL1815386
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Antitumor against human CNE2 cells assessed as cell survival after 48 hrs by MTT assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CNE-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.07 | 5.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273862 | HYDROXYCAMPTOTHECIN | 3.0 | 1 | 5.98 |
| CHEMBL1812139 | — | — | 1 | 5.69 |
| CHEMBL1812130 | — | — | 1 | 5.54 |
| CHEMBL1812136 | — | — | 1 | 5.50 |
| CHEMBL1812132 | — | — | 1 | 5.45 |
| CHEMBL1812133 | — | — | 1 | 5.45 |
| CHEMBL1812143 | — | — | 1 | 5.41 |
| CHEMBL1812137 | — | — | 1 | 5.35 |
| CHEMBL1812149 | — | — | 1 | 5.32 |
| CHEMBL1812144 | — | — | 1 | 5.28 |
| CHEMBL1812151 | — | — | 1 | 5.24 |
| CHEMBL1812131 | — | — | 1 | 5.20 |
| CHEMBL1812147 | — | — | 1 | 5.19 |
| CHEMBL1812129 | — | — | 1 | 5.09 |
| CHEMBL1812140 | — | — | 1 | 5.09 |
| CHEMBL1812146 | — | — | 1 | 5.04 |
| CHEMBL1812138 | — | — | 1 | 5.01 |
| CHEMBL1812134 | — | — | 1 | 4.87 |
| CHEMBL1812148 | — | — | 1 | 4.80 |
| CHEMBL1812135 | — | — | 1 | 4.76 |
| CHEMBL1812142 | — | — | 1 | 4.67 |
| CHEMBL1812145 | — | — | 1 | 4.56 |
| CHEMBL197655 | MANSONONE F | — | 1 | 4.56 |
| CHEMBL1812160 | — | — | 1 | 4.52 |
| CHEMBL1812158 | — | — | 1 | 4.52 |
| CHEMBL1812141 | — | — | 1 | 4.48 |
| CHEMBL1812156 | — | — | 1 | 4.40 |
| CHEMBL1812159 | — | — | 1 | - |
| CHEMBL1812153 | — | — | 1 | - |
| CHEMBL1812157 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273862 | HYDROXYCAMPTOTHECIN | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL1812139 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL1812130 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL1812136 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL1812132 | — | IC50 | = | 3590.0 | nM | 5.45 |
| CHEMBL1812133 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL1812143 | — | IC50 | = | 3930.0 | nM | 5.41 |
| CHEMBL1812137 | — | IC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL1812149 | — | IC50 | = | 4830.0 | nM | 5.32 |
| CHEMBL1812144 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL1812151 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL1812131 | — | IC50 | = | 6340.0 | nM | 5.20 |
| CHEMBL1812147 | — | IC50 | = | 6520.0 | nM | 5.19 |
| CHEMBL1812129 | — | IC50 | = | 8120.0 | nM | 5.09 |
| CHEMBL1812140 | — | IC50 | = | 8050.0 | nM | 5.09 |
| CHEMBL1812146 | — | IC50 | = | 9190.0 | nM | 5.04 |
| CHEMBL1812138 | — | IC50 | = | 9760.0 | nM | 5.01 |
| CHEMBL1812134 | — | IC50 | = | 13450.0 | nM | 4.87 |
| CHEMBL1812148 | — | IC50 | = | 15970.0 | nM | 4.80 |
| CHEMBL1812135 | — | IC50 | = | 17330.0 | nM | 4.76 |
| CHEMBL1812142 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL1812145 | — | IC50 | = | 27480.0 | nM | 4.56 |
| CHEMBL197655 | MANSONONE F | IC50 | = | 27340.0 | nM | 4.56 |
| CHEMBL1812160 | — | IC50 | = | 30430.0 | nM | 4.52 |
| CHEMBL1812158 | — | IC50 | = | 30350.0 | nM | 4.52 |
| CHEMBL1812141 | — | IC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL1812156 | — | IC50 | = | 39470.0 | nM | 4.40 |
| CHEMBL1812159 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1812153 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1812157 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1812155 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1812154 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1812150 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1812152 | — | IC50 | > | 50000.0 | nM | - |